Os principais efeitos da administração de dhea em mulheres na pós-menopausa: uma revisão sistemática

Abstract

Introduction: Dehydroepiandrosterone (DHEA) is a hormonal precursor synthesized from cholesterol by the adrenal gland cortex with the aid of mitochondrial enzymes. It appears in the body in its sulfated form (DHEAS) and performs several functions in the body. The administration of this steroid significantly influences several endocrine parameters in postmenopausal women, in the control of estrogen and progesterone and is also related to the gain of muscle mass. However, the inappropriate use of DHEA can carry great risks to human health. Objective: To evaluate the effects of DHEA administration in postmenopausal women. Methods: Complete, original and indexed scientific articles related to the topic, written in English, found in the CAPES / MEC Journal Portal, PubMed databases were used; Lilacs and Scielo, published between 2009 and 2019. To ensure methodological quality, the “Checklist Downs and Black” technique was used. Results: Initially, 131 articles were selected for study and evaluation of their contents, after reading and adapting to the theme of this work, only were used to discuss this systematic review. Conclusion: It was possible to identify the presence of positive systemic and local effects after DHEA administration in postmenopausal women. However, these studies are not very consistent in drawing conclusions about the use of DHEA.