A Relação da Microbiota Intestinal e dos Receptores Toll-like na Ativação do Sistema Imunológico nos Estados de Saúde e Doença: Uma Revisão de Literatura

Abstract

Considering that the number of inflammatory bowel diseases has increased significantly worldwide and mainly in the West, research is carried out on the relationship between the immune system, more precisely toll-like receptors, and the intestinal microbiota, in order to understand how this relationship is able to affect the individual's health status. Therefore, it is necessary to understand the relationship between parasite and host, the concept of intestinal microbiota and the main microorganisms and their substrates found in our intestine, the concept and types of toll-like receptors and their functions and, finally, it is necessary to address the syndromes metabolic disorders arising from intestinal inflammation such as obesity and diabetes. A literature review is then carried out with updated scientific articles taken from renowned databases such as Pubmed and Science Direct. In view of this, it appears that TLRs are of paramount importance for an effective immune response, but they are sometimes great villains in inflammatory bowel diseases, and the intestinal microbiota in turn, provided that under homeostasis conditions, it is indispensable for prevention. and control of several disorders, which imposes the finding that the relationship between intestinal microbiota and toll-like receptors significantly interferes in the health and disease states of an individual.