Associação Da Relação Neutrófilo/linfócito Com A Gravidade Da Covid-19: Uma Revisão Sistemática

Abstract

Peripheral blood inflammatory parameters change significantly with the progression of the disease, so it is important to analyze these parameters upon hospital admission. Studies have reported that the neutrophil/lymphocyte ratio (NLR) value is elevated in severe cases of COVID-19, and it can predict the severity and mortality of infected patients. Thus, it is necessary to investigate possible changes in NLR values to aid in the prognosis and progression of the disease. This systematic review aimed to analyze, based on the literature, the association of NLR with the severity of patients with COVID-19. A bibliographic search was conducted in the PUBMED database, including studies published between February 2020 and June 2022. A total of 38 studies, comprising 9.865 patients, were considered. Patients with an NLR value higher than 3.13 were more likely to develop severe disease and were closely linked to mortality. Other studies showed that patients with an NLR value greater than 6.7 should receive greater care as they are considered critically ill. The optimal cutoff value to predict in-hospital patient mortality is 11.38. NLR was valuable as a prognostic predictor of COVID-19 infection during the pandemic.