Avanços Terapêuticos no Uso de Canabidiol em Perfil de Idosos com Alzheimer: Uma Revisão Integrativa da Literatura

Abstract

Alzheimer's Disease (AD) is of a common, progressive character that destroys memory and other important mental functions, but commonly in the elderly, with neuropsychiatric symptoms referring to biochemical and neuroanatomical changes and in the region of the cerebral cortex. Studies show that the use of cannabidiol (CBD) and tetrahydrocannabinol (THC) act on the central nervous system, which is considered promising for the treatment of patients with AD. The present study had as its general objective, in a literature review, to evaluate the therapeutic potential in the use of cannabidiol in the profile of elderly people with Alzheimer's disease, with specific objectives: to evaluate the therapeutic potential of cannabidiol in the application to Alzheimer's Disease, aiming at the importance of scientific advances , and implications for the use of CBD. As for the methodology, it is an integrative review of the literature of an exploratory qualitative nature, with a theoretical approach of a descriptive nature. The Scientific Electronic Library Online (SCIELO), National Library of

Medicine (PUBMED), and Google Scholar databases were consulted. Using as Descrip- tors, the terms: dementia syndrome; Alzheimer's disease; cannabis; phytocannabinoids; ç.

sativa; cannabinoids; cannabidiol; CBD; tetrahydrocannabinol; THC. The results evidenced the use of cannabidiol with high therapeutic potential, to delay the evolution of Alzheimer's disease in patients of advanced age, by studies that prove the pharmacodynamic and pharmacokinetic safety of low oral doses of THC in the elderly for the progress of memory and functions brains, highlighting the importance of legislation to authorize the medical use

of cannabis for treatment. Cannabidiol is considered efficient in the treatment of Alzhei- mer's Disease (AD), aiming at the importance of medical prescription for safer use. Thus,

the neuroprotective effects of cannabinoids act on the patient's cognitive, behavioral and learning improvement.