Modificação química de polissacarídeo obtido a partir de Exsudato com anidrido propiônico

Abstract

Tree exudated gums are natural polymers that represent an abundant raw material in the food or pharmaceutical industry. Exudating trees of the genus Anacardium, a species native to northeastern Brazil, can obtain cashew gum. Its polymer is composed of monosaccharide units that are prone to the action of chemical reactions that tend to improve their intrinsic characteristics, such as the degree of hydrosolubility. Thus, this work aimed the esterification of cashew gum (GC) with propionic anhydride in order to investigate its activities regarding biocompatibility, antimicrobial activity and nanostructured system formulation. The chemical modification was verified by Fourier Transform Infrared Spectroscopy (FT-IR) comparing the cashew gum (GC) spectra with the propionic anhydride modified cashew gum (GCMAP). After the modification, the GCMAP Relative Substitution Degree of 6.274 was verified. For the analysis of the degree of structural organization the X-ray Diffraction (XRD) technique was used comparing the derived material with the starting material. The GCMAP derivative showed no antibacterial effect against S. aureus and E. coli. However, it was satisfactory in hemolytic assays against human erythrocytes, showed no cytotoxic activity against the strains tested (HCT-116, NCI-H460 and MRC-5), and was satisfactory for the nanoparticle formulation examined by the absorption spectra in the region. Visible UV, Zeta Potential and DLS spectroscopy. The derived biopolymers are promising biomaterials for use in biotechnological applications