Avaliação da atividade anti-inflamatória de frações de licopeno da goiaba

Abstract

Experimental models at rats have shown that lycopene from different sources, or fractions rich in lycopene, perform important role in modulation of inflammation. The objective this work is to evaluate the anti-inflammatory activity of lycopene from red guava (Psidium guajava L.), as lycopene extract (ELG) and lycopene purified (LPG). The anti-inflammatory

activity was initially tested by carrageenan-induced paw edema model and the anti- edematogenic mechanism was verified by paw edema induced by different agents. The effect

of LPG 12,5 mg/kg on neutrophil migration, myeloperoxidase (MPO) activity and glutathione (GSH) levels was measured by peritonitis model. The results demonstrate ELG (50 mg/kg i.p. and 100 mg/kg p.o.) and LPG (12,5 mg/kg p.o.) showed the maximum inhibitory effect, with 80,33%, 80,33% and 70,49% of inhibition, respectively, considering third hour after edema induction. LPG (12,5 mg/kg p.o.) inhibited formation of paw edema induced by dextran, compound 48/80, histamine and prostaglandin E2; reduced significantly leukocyte migration and neutrophil recruitment to peritoneal cavity, reduced MPO activity and showed redox- protective action, suggested by the increased GSH levels. The results demonstrate that lycopene from guava confer beneficial effects against acute inflammation and opens prospects for further studies.