Avaliação da Toxicidade Aguda da Goma Extraída do Exsudato da Seriguela (spondias Purpurea L.) em Camundongos Balb/c

Abstract

Medicinal plants were used in various ways as a means of curing diseases. Throughout history, the belief that herbal remedies are safer since they are a natural compound. Howe ver, some compounds present in plants are or have toxic characteristics. Seriguela (Spondias purpurea L.) is a fruit native to Brazil, used medicinally and with great potential for therapeutic purposes. The objective was to analyze the acute toxicity of the gum, according to the Acute Toxic Class Method (OECD). The protocol was performed according to OECD 423/2001 guidelines. Animals received a single dose of 2000 mg/kg. The Evolution of Hippocratic screening was performed, the animals Where evaluated at 10 mim, 30 min, 1h, 2h, 4h, 6h, 12h and 24h after dosing. Evaluating them once daily until day 14 after treatment. On the 15th day after treatment, the animals were euthanized, then the biochemical and hematological parameters, the relative weight of the organs and histopathological analysis were analyzed. Results were expressed as mean ± standard deviation. Analyzes performed throughout the toxicity test period demonstrated that the 2,000 mg/kg dose administered to the seriguela gum (GS) group did not result in animal death or toxic side effects. The value determined for the DL50 after oral administration of GS was estimated to be more than 2000 mg/kg.